Clinical and Diagnostic Significance of Endothelial Dysfunction and Myocardial Contractility in Patients With AML

Careful history taking, including using questionnaires, to identify risk factors for the development of cardiovascular diseases using the SCORE scale.

Anthropometry: measurement of body weight and height. Calculation of body surface area using the Du Bois formula.

Before and after each course of chemotherapy: Complete blood count with counting the number of erythrocytes, leukocytes, leukocyte formula, platelets, erythrocyte sedimentation rate.

Before and after each course of chemotherapy: Biochemical blood test with the determination of the amount of total protein, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, creatinine, urea, AlAT, AsAT, LDH, glucose, C-reactive protein, troponin T, proBNP.

Before and after each course of chemotherapy: Coagulogram parameters (fibrinogen, APTT, INR).

Before the start of the treatment and after each course of chemotherapy: Immunoenzymatic analysis of the level of endothelin-1, asymmetric dimethylarginine.

Before the start of the treatment and after each course of chemotherapy: Stress echocardiography with the definition of global longitudinal deformation of the myocardium.

Before the start of the treatment and after each course of chemotherapy: Triplex scanning of neck vessels.

Before and after each course of chemotherapy: Electrocardiography.

Before the start of the treatment and after each course of chemotherapy: Ultrasound of the abdominal cavity (with calculation of the area of the spleen) and lymph nodes.

Before the start of the treatment: Cytogenetic examination of the bone marrow to determine genetic abnormalities.

Before the start of the treatment and after each course of chemotherapy: Cytological examination of bone marrow cells with cytochemical examination.

Before the start of the treatment: Immunophenotypic examination of the bone marrow by flow cytometry.

Before the start of the treatment: Determination of the presence of a FLT3 mutation using the PCR Method.

Before the start of the treatment and after each course of chemotherapy: Examination of microcirculation by laser Doppler flowmetry using the LAKK-OP apparatus (NPP Lazma, Moscow, 2011) with respiratory and occlusion tests.