Selinexor in Combination With MTX+Ritu to Treat R/R CNSL

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

August 3, 2023

Primary Completion Date

June 30, 2026

Study Completion Date

December 31, 2026

Conditions
Central Nervous System Lymphoma
Interventions
DRUG

Selinexor

"Selinexor dose escalation: 60,80,100mg respectively on day 1,8,15,22 for 28 days cycles, and dose expansion at the RP2D of Selinexor.~PR patients after induction treatment will continue ATG-010 maintenance up to 1 year or until disease progression, intolerable toxicity, death."

DRUG

Rituximab

Rituximab 375 mg/m2 intravenous infusion d1, every 28 days for 6 cycles during combination induction treatment.

DRUG

Methotrexate

high-dose Methotrexate 3.5 g/m2 intravenous infusion d1, every 28 days for 6 cycles during combination induction treatment.

Trial Locations (5)

200040

RECRUITING

Department of Hematology, Huashan Hospital, Fudan University, Shanghai

450052

NOT_YET_RECRUITING

Oncology Department of The First Affiliated Hospital of Zhengzhou University, Zhengzhou

Unknown

NOT_YET_RECRUITING

The First Affiliated Hospital Of Anhui Medical University, Hefei

NOT_YET_RECRUITING

Beijing Tiantan Hospital, Capital Medical University, Beijing

NOT_YET_RECRUITING

The First Affiliated Hospital Of Fujian Medical University, Fuzhou

All Listed Sponsors
collaborator

Antengene Corporation

INDUSTRY

lead

Tong Chen, MD

OTHER