Trial to Model Primary, Secondary, and Tertiary Dengue Using a Monovalent Vaccine

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

127

Participants

Timeline

Start Date

March 7, 2023

Primary Completion Date

April 23, 2025

Study Completion Date

May 1, 2026

Conditions
Response To Dengue Exposure
Interventions
DRUG

rDENdelta30/31-7164

The rDEN3delta30/31-7164 vaccine is a live attenuated virus constructed by creating two deletions in the 3 UTR of the DENV3 Sleman/78 strain. The rDEN3delta30/31-7164 vaccine will be delivered subcutaneously into the left deltoid area on day 0. The vaccine dose will consist of 0.5 mL of 10\^3 PFU/mL of rDEN3delta30/31-7164 plus Plasma-Lyte A pH 7.4 diluent.

Trial Locations (1)

20892

National Institutes of Health Clinical Center, Bethesda

All Listed Sponsors
lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH