A Study of Short-Course Radiation Therapy With Chemotherapy in People With Endometrial Cancer

EARLY_PHASE1RecruitingINTERVENTIONAL
Enrollment

28

Participants

Timeline

Start Date

January 10, 2023

Primary Completion Date

January 10, 2026

Study Completion Date

January 10, 2026

Conditions
Endometrial CancerStage III Endometrial CancerStage III Endometrial CarcinomaEndometrial CarcinomaEndometrial Carcinoma Stage III
Interventions
RADIATION

Intensity-modulated radiation therapy

After cycles 1, 2, 3 or 4 of chemotherapy, patients will receive IMRT to the vaginal cuff and pelvic lymph nodes with a total dose of 25 Gy delivered in 5 daily fractions of 5 Gy

DRUG

Carboplatin

Patients enrolled in this trial will receive chemotherapy with carboplatin IV AUC 5 at the discretion of the treating investigator plus paclitaxel 175 mg/m2 every 21 days for 6 cycles

DRUG

Paclitaxel

Patients enrolled in this trial will receive chemotherapy with carboplatin IV AUC 5 at the discretion of the treating investigator plus paclitaxel 175 mg/m2 every 21 days for 6 cycles

Trial Locations (7)

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

10604

RECRUITING

Memorial Sloan Kettering Westchester (All protocol activities), Harrison

11553

RECRUITING

Memorial Sloan Kettering Nassau (All protocol activities), Uniondale

11725

RECRUITING

Memorial Sloan Kettering Commack (All protocol activities), Commack

07920

RECRUITING

Memorial Sloan Kettering Basking Ridge (All protocol activities), Basking Ridge

07748

RECRUITING

Memorial Sloan Kettering Monmouth (All protocol activities), Middletown

07645

RECRUITING

Memorial Sloan Kettering Bergen (All protocol activities), Montvale

All Listed Sponsors
lead

Memorial Sloan Kettering Cancer Center

OTHER