FocaL Mass Drug Administration for Vivax Malaria Elimination

PHASE3RecruitingINTERVENTIONAL
Enrollment

7,530

Participants

Timeline

Start Date

October 14, 2024

Primary Completion Date

May 1, 2027

Study Completion Date

May 1, 2027

Conditions
Malaria, VivaxMalaria
Interventions
DRUG

Focal Mass Drug Administration (fMDA)

"Administration of focal mass drug administration for high-risk individuals residing in households that are within 200 meters of a Plasmodium vivax index case households from the prior 2 years (including individuals in the index case household). Intervention to be administered two times, two months apart each cycle, for 3 cycles spaced apart by regular intervals.~Each year will include 2 rounds of fMDA.~Round 1) Chloroquine (CQ)+ Tafenoquine (TQ) for \>= 16y (CQ: Day1 600 mg, Day 2 600 mg, Day 3 300 mg CQ, TQ 300 mg on Day 1); CQ+ Primaquine (PQ) for \<16y (CQ: age-based dosing, PQ age-based dosing); CQ+PQ for G6PD intermediate individuals \>=6mo and \<16y ((CQ: Day1 600 mg, Day 2 600 mg, Day 3 300 mg, PQ age-based dosing).~Round 2) single dose CQ+TQ for \>= 16y (CQ: Day1 600 mg, TQ 300 mg on Day 1); single dose CQ+PQ for \<16y (CQ: age-based dosing, PQ age-based dosing); single dose CQ+PQ for G6PD intermediate individuals \>=6mo and \<16y ((CQ: Day1 600 mg, PQ age-based dosing)."

Trial Locations (1)

Unknown

RECRUITING

Asociación Civil Selva Amazónica, Iquitos

All Listed Sponsors
collaborator

Universidad Peruana Cayetano Heredia- subcontractor to UCSF as local Sponsor

UNKNOWN

collaborator

PATH

OTHER

collaborator

Stanford University

OTHER

collaborator

Oxford University Clinical Research Unit Indonesia

OTHER

collaborator

Menzies School of Health Research

OTHER

collaborator

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

lead

University of California, San Francisco

OTHER

NCT05690841 - FocaL Mass Drug Administration for Vivax Malaria Elimination | Biotech Hunter | Biotech Hunter