NCT05673772View on ClinicalTrials.gov

Preoperative Sequential Short-course Radiation Therapy and FOLFOX for Locally Advanced Rectal Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

364

Participants

Timeline

Start Date

October 23, 2020

Primary Completion Date

June 30, 2025

Study Completion Date

December 31, 2029

Conditions
Rectal Cancer
Interventions
RADIATION

short-course radiotherapy

25 Gy in 5 fractions for 5 days

DRUG

mFOLFOX6

Oxaliplatin 85 mg/m2, Levoleucovorin 200mg (or Leucovroin, Leucosodium 400mg)/m2, 5- FU 400 mg/m2, and continuous 5- FU 2,400 mg/m2 for 46 hours

RADIATION

Chemoradiotherapy

45\~50.4 Gy/25fr with concurrent use of either capecitabine or 5-FU+leucovorin(or levoleucovorin or leucosodium)

PROCEDURE

TME surgery

TME surgery

Trial Locations (9)

702-210

RECRUITING

Gyu seog Choi, Daegu

Unknown

RECRUITING

Chungnam National University Hospital, Daejeon

RECRUITING

Chonnam National University Hwasun Hospital, Gwangju

RECRUITING

Catholic University of Korea Incheon St. Mary's Hospital, Incheon

RECRUITING

Jeonbuk National University Hospital, Jeonju

RECRUITING

, Korea University Anam Hospital, Seoul

RECRUITING

Gangnam Severance Hospital, Seoul

RECRUITING

Seoul National University Bundang Hospital, Seoul

05505

RECRUITING

Asan Medical Center, Seoul

All Listed Sponsors
collaborator

National Cancer Center, Korea

OTHER_GOV

lead

Kyungpook National University Hospital

OTHER