43
Participants
Start Date
April 26, 2023
Primary Completion Date
August 30, 2024
Study Completion Date
August 30, 2024
Iohexol measurement
Invasive renal hemodynamic measurement of mGFR through the administration of Iohexol.
Geranylgeranylacetone (GGA)
13 weeks of treatment with GGA/placebo orally, followed by a wash-out period of 6 weeks, then reversal of the treatment arms.
Echocardiography
The investigators will perform echocardiography to find changes in cardiac function.
6-minute walking distance test
6 minute walking distance test to compare exercise tolerance in participants.
EndoPAT
Use of EndoPAT to measure endothelial function.
Para-amino Hippuric Acid test
PAH-measurement to measure ERPF.
Electrocardiogram
12-lead Electrocardiogram
Amsterdam UMC, loc VUmc, Amsterdam
Amsterdam UMC, location VUmc
OTHER