Dose-ranging Study to Evaluate the Efficacy, Safety, and Tolerability of AMG 133 in Adult Subjects With Overweight or Obesity, With or Without Type 2 Diabetes Mellitus

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

592

Participants

Timeline

Start Date

January 18, 2023

Primary Completion Date

October 8, 2024

Study Completion Date

January 2, 2026

Conditions
ObesityOverweightType 2 Diabetes Mellitus
Interventions
BIOLOGICAL

Maridebart Cafraglutide

Participants will receive maridebart cafraglutide by subcutaneous (SC) injection.

DRUG

Placebo

Participants will receive placebo by SC injection.

Trial Locations (78)

1021

Budapesti Szent Ferenc Korhaz, Budapest

1033

Clinexpert Kft, Budapest

2006

Royal Prince Alfred Hospital (RPAH) Clinic, Camperdown

3004

Baker Heart and Diabetes Institute, Melbourne

3065

St Vincents Hospital Melbourne, Fitzroy

3081

Austin Health, Heidelberg Repatriation Hospital, Heidelberg Heights

3146

Monash Medical Centre, Clayton

3860

CRU Hungary Kft, Encs

5000

Clinical Medical and Analytical eXellence CMAX, Adelaide

7624

Pecsi Tudomanyegyetem Klinikai Kozpont, Pécs

10002

National Taiwan University Hospital, Taipei

10117

Charite - Universitaetsmedizin Berlin, Campus Mitte, Berlin

10326

Dongguk University Ilsan Hospital, Goyang-si, Gyeonggi-do

13210

State University of New York Upstate Medical University, Syracuse

13620

Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do

15006

Complexo Hospitalario Universitario A Coruña, A Coruña

21565

Gachon University Gil Medical Center, Incheon

22607

Diabeteszentrum Hamburg West, Hamburg

25198

Hospital Universitario Arnau de Vilanova Lleida, Lleida

28557

Lucas Research, Morehead City

29010

Hospital Clinico Universitario Virgen de la Victoria, Málaga

32127

Progressive Medical Research, Port Orange

33134

Alliance for Multispecialty Research Miami, Coral Gables

36608

Alliance for Multispecialty Research Mobile, Mobile

37643

Medical Care LLC, Elizabethton

40213

Louisville Metabolic and Atherosclerosis Research Center, Louisville

40447

China Medical University Hospital, Taichung

41950

Hospital Vithas Sevilla, Castilleja de la Cuesta

45219

The Christ Hospital, Cincinnati

45431

Research Innovations LLC dba Internal Medicine Care Inc, Beavercreek

60637

University of Chicago, Chicago

60640

Great Lakes Clinical Trials, Chicago

63303

StudyMetrix Research, City of Saint Peters

64114

Alliance for Multispecialty Research Kansas City, Kansas City

67114

Alliance for Multispecialty Research Newton, Newton

70072

Tandem Clinical Research - Marrero, Marrero

70403

National Cheng Kung University Hospital, Tainan City

73069

Alliance for Multispecialty Research Norman, Norman

78229

Clinical Trials of Texas, San Antonio

Diabetes and Glandular Disease Clinic, San Antonio

Pinnacle Clinical Research, San Antonio

78284

Texas Diabetes Institute, San Antonio

78520

PanAmerican Clinical Research LLC, Brownsville

78526

Headlands Research Brownsville, Brownsville

80756

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

85044

Foothills Research Center, Phoenix

85258

HonorHealth, Scottsdale

90815

Ark Clinical Research- Long Beach, Long Beach

92780

Ark Clinical Research- Tustin, Tustin

Orange County Research Center, Tustin

94598

Diablo Clinical Research, Walnut Creek

96814

East-West Medical Research, Honolulu

T2T 5C7

University of Calgary, Calgary

L6S 0C6

Centricity Research Brampton Endocrinology, Brampton

L4K 4M2

Centricity Research Vaughan Endocrinology, Concord

G1V 4G5

Institut Universitaire de cardiologie et de pneumologie de Quebec, Québec

G1V 4W2

Clinique des Maladies Lipidiques de Quebec Incorporated, Québec

116 94

Endokrinologicky ustav, Prague

128 08

Vseobecna fakultni nemocnice v Praze, Prague

140 21

Institut klinicke a experimentalni mediciny, Prague

04103

Universitaetsmedizin Leipzig, Leipzig

Unknown

Prince of Wales Hospital, Shatin, New Territories

790-0034

Mikannohana Clinic, Diabetes, Endocrinology and Metabolism, Matsuyama

810-0001

Wellness Tenjin Clinic, Fukuoka

501-6061

Matsunami Health Promotion Clinic, Hashima-gun

735-8585

Mazda Hospital of Mazda Motor Corporation, Aki-gun

311-0113

Nakakinen Clinic, Naka

311-0133

Nishiyamado Keiwa Hospital, Naka

582-0005

Shiraiwa Medical Clinic, Kashiwara-shi

103-0025

Nihonbashi Sakura Clinic, Chuo-ku

151-0051

MIH Clinic Yoyogi, Shibuya-ku

85-752

AthleticoMed, Bydgoszcz

80-546

Centrum Badan Klinicznych PI-House Spzoo, Gdansk

90-338

Centrum Terapii Wspolczesnej, Lodz

90-349

AppleTreeClinics Network Spzoo, Lodz

20-078

Clinical Best Solutions Sp zoo Spolka Komandytowa, Lublin

52-210

Migre Polskie Centrum Leczenia Migreny Anna Gryglas-Dworak, Wroclaw

03181

Kangbuk Samsung Hospital, Seoul

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY

NCT05669599 - Dose-ranging Study to Evaluate the Efficacy, Safety, and Tolerability of AMG 133 in Adult Subjects With Overweight or Obesity, With or Without Type 2 Diabetes Mellitus | Biotech Hunter | Biotech Hunter