Restor. I-131 Upt. + Selpercatinib in RET F-P RAI-R TC

PHASE2RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

March 1, 2023

Primary Completion Date

March 1, 2025

Study Completion Date

January 1, 2026

Conditions
Thyroid CancerThyroid CarcinomaMetastatic Thyroid CancerFollicular Thyroid CancerUnresectable Thyroid Gland CarcinomaPapillary Thyroid Cancer
Interventions
DRUG

Selpercatinib

Selpercatinib Oral, twice daily during initial treatment period (28 Days). A second course of selpercatinib if the participant is demonstrating clinical benefit to the initial course selpercatinib and deemed clinically appropriate by the treating investigator

DRUG

Sodium Iodine I-131

I-131 NaI, oral, is a standard treatment for all types of follicular-derived thyroid cancers, except anaplastic thyroid cancer

DRUG

rhTSH

"RhTSH injection, dosage per protocol, timing per protocol during the initial treatment period per standard of care.~Participants may receive a second course of rhTSH if the participant is demonstrating clinical benefit to the initial course rhTSH and deemed clinically appropriate by the treating investigator."

Trial Locations (6)

19104

RECRUITING

Children's Hospital of Philadelphia, Philadelphia

20010

RECRUITING

MedStar Washington Hospital Center, Washington D.C.

33612

RECRUITING

Moffitt Cancer Center, Tampa

48109

RECRUITING

University of Michigan, Ann Arbor

77030

RECRUITING

MD Anderson Cancer Center, Houston

02115

RECRUITING

Massachusetts General Hospital, Boston

All Listed Sponsors
collaborator

Eli Lilly and Company

INDUSTRY

lead

Massachusetts General Hospital

OTHER