A Phase 1/2 Study of VX-522 in Participants With Cystic Fibrosis (CF)

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

39

Participants

Timeline

Start Date

February 27, 2023

Primary Completion Date

December 23, 2026

Study Completion Date

May 12, 2027

Conditions
Cystic Fibrosis
Interventions
DRUG

VX-522 mRNA therapy

Oral inhalation using nebulizer.

DRUG

IVA

Tablet for oral administration.

Trial Locations (42)

10028

ACTIVE_NOT_RECRUITING

Medicine at East 85th Street, New York

10032

ACTIVE_NOT_RECRUITING

Presbyterian Hospital - Pulmonology, New York

15224

ACTIVE_NOT_RECRUITING

Children's Hospital of Pittsburgh - Pulmonology, Pittsburgh

21225

COMPLETED

PAREXEL International - Baltimore, Baltimore

21287

ACTIVE_NOT_RECRUITING

The Johns Hopkins University - Johns Hopkins Hospital - Pulmonology, Baltimore

29425

ACTIVE_NOT_RECRUITING

Medical University of South Carolina - Pulmonology, Charleston

32610

ACTIVE_NOT_RECRUITING

Shands Hospital - Pulmonology, Gainesville

35233

ACTIVE_NOT_RECRUITING

Child Health Research Unit, Birmingham

37232

ACTIVE_NOT_RECRUITING

Vanderbilt Interventional Pulmonology, Nashville

43205

ACTIVE_NOT_RECRUITING

Nationwide Children's Hospital, Columbus

44106

ACTIVE_NOT_RECRUITING

UH Cleveland Medical Center - Pulmonology, Cleveland

45220

ACTIVE_NOT_RECRUITING

UC Health Holmes Hospital, Cincinnati

53792

ACTIVE_NOT_RECRUITING

University of Wisconsin Hospital and Clinics, Madison

55455

RECRUITING

University of Minnesota -Pulmonology, Minneapolis

60611

ACTIVE_NOT_RECRUITING

Northwestern Memorial Hospital - Feinberg Pavilion, Chicago

63110

COMPLETED

St. Louis Children's Hospital - Pulmonology, St Louis

66160

ACTIVE_NOT_RECRUITING

Clinical & Translational Science Unit (CTSU) - Pulmonology, Kansas City

77030

ACTIVE_NOT_RECRUITING

Texas Children's Hospital - Wallace Tower - Pulmonology, Houston

80206

ACTIVE_NOT_RECRUITING

National Jewish Health, Denver

84132

ACTIVE_NOT_RECRUITING

University of Utah Hospital - Pulmonology, Salt Lake City

90806

ACTIVE_NOT_RECRUITING

Memorial Health Services on behalf of Long Beach Memorial Medical Center d/b/a Miller Children's Hospital Long Beach, Long Beach

94304

ACTIVE_NOT_RECRUITING

Stanford University - Palo Alto - Pulmonology, Palo Alto

02114

ACTIVE_NOT_RECRUITING

MGH - MGfC Pediatric Cystic Fibrosis Center, Boston

02115

ACTIVE_NOT_RECRUITING

Boston Children's Hospital, Boston

Unknown

ACTIVE_NOT_RECRUITING

The Alfred Hospital - Pulmonology, Melbourne

ACTIVE_NOT_RECRUITING

Universitair Ziekenhuis Gent, Ghent

ACTIVE_NOT_RECRUITING

University of Calgary Medical Clinic of the Foothills Medical Centre, Calgary

ACTIVE_NOT_RECRUITING

IUCPQ Pavillon Recherche U-1771, Québec

ACTIVE_NOT_RECRUITING

Ruhrlandklinik, Essen

ACTIVE_NOT_RECRUITING

IRCCS Istituto Giannina Gaslini-Ospedale Pediatrico - Pulmonology, Genova

ACTIVE_NOT_RECRUITING

Centro Ricerche Cliniche di Verona S.r.l., Verona

WITHDRAWN

UMCU - Department of Pulmonology and Tuberculosis, Utrecht

ACTIVE_NOT_RECRUITING

Hospital Universitari Vall d´Hebron Servicio de Broncoscopia, Barcelona

ACTIVE_NOT_RECRUITING

Hospital Virgen del Rocio - Pulmonology, Seville

ACTIVE_NOT_RECRUITING

Hospital Universitario y Politecnico La Fe - Pulmonology, Valencia

ACTIVE_NOT_RECRUITING

Karolinska University Hospital - Pulmonology, Stockholm

COMPLETED

Papworth Hospital NHS Foundation Trust, Cambridge

COMPLETED

Queen Elizabeth University Hospital - Pulmonology, Glasgow

ACTIVE_NOT_RECRUITING

Royal Brompton Hospital, London

ACTIVE_NOT_RECRUITING

Wythenshawe Hospital - OPD, Manchester

RECRUITING

All Wales Adult Cystic Fibrosis Centre, University Hospital Llandough, Penarth

ACTIVE_NOT_RECRUITING

University Hospital Southampton NHS Fountion - Southampton General Hospital, Southampton

All Listed Sponsors
collaborator

Moderna, Inc

UNKNOWN

lead

Vertex Pharmaceuticals Incorporated

INDUSTRY