A Study to Characterize the Safety, Tolerability, and Preliminary Efficacy of CFT1946 as Monotherapy and Combination Therapy in Subjects With BRAF V600 Mutant Solid Tumors

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

89

Participants

Timeline

Start Date

December 8, 2022

Primary Completion Date

March 11, 2027

Study Completion Date

April 11, 2027

Conditions
Solid TumorsMelanomaNSCLCCRCATC
Interventions
DRUG

CFT1946

Specified oral dose on specified day

DRUG

Trametinib

Specified oral dose on specified day

DRUG

Cetuximab

Specified intravenous dose on specified day

Trial Locations (26)

10021

David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center, New York

22031

Virginia Cancer Specialists (NEXT Oncology Virginia), Fairfax

23007

Complejo Hospitalario de Jaen, Jaén

28007

Hospital General Universitario Gregorio Maranon, Madrid

28040

South Texas Accelerated Research Therapeutics (START) Madrid - Hospital Fundacion Jiminez Diaz, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

31059

IUCT Oncopole, Toulouse

33076

Institut Bergonie, Bordeaux

34232

Florida Cancer Specialists, Sarasota

37203

Sarah Cannon and HCA Research Institute, Nashville

45147

Universitaetsklinikum Essen, Essen

46010

Hospital Clinico Universitario de Valencia, Valencia

46250

Community Health Network, Indianapolis

53792

University of Wisconsin, Madison

55407

Allina Health System DBA Virginia Piper Cancer Institute, Minneapolis

59037

Chu de Lille, Lille

63110

Washington University School of Medicine, St Louis

69008

Centre Leon Berard, Lyon

77030

MD Anderson Cancer Center, Houston

85719

University of Arizona - Cancer Center, Tucson

02215

Dana-Farber Cancer Institute, Boston

Unknown

"KEM , Evang. Kliniken Essen-Mitte gGmbH"

08023

NEXT Oncology Barcelona, Barcelona

08035

Hospital Universitario Vall d'Hebron, Barcelona

G12 0YN

Beatson West of Scotland Cancer Centre, Glasgow

M20 4BX

The Christie NHS Foundation Trust, Manchester

Sponsors
All Listed Sponsors
lead

C4 Therapeutics, Inc.

INDUSTRY