Administration of Venetoclax to Promote Apoptosis of HIV-infected Cells and Reduce the Size of the HIV Reservoir Among People Living With HIV on ART

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

18

Participants

Timeline

Start Date

April 1, 2024

Primary Completion Date

March 1, 2026

Study Completion Date

December 1, 2026

Conditions
HIV-1-infection
Interventions
DRUG

Venetoclax

In this study participants will receive venetoclax 200 mg, 400 mg or 800 mg once daily for 14 days in the dose-escalation phase. In the expansion cohort, the selected max-tolerated dose will be given for three cycles, each consisting of venetoclax daily for 14 days followed by 14 days off.

Trial Locations (1)

Unknown

RECRUITING

Aarhus University Hospital, Aarhus

All Listed Sponsors
collaborator

The Peter Doherty Institute for Infection and Immunity

OTHER

collaborator

Walter and Eliza Hall Institute of Medical Research

OTHER

collaborator

The Alfred

OTHER

collaborator

Aarhus University Hospital

OTHER

lead

University of Aarhus

OTHER