Treatment of Advance Gastric Cancer With Disulfiram

NANot yet recruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

June 1, 2023

Primary Completion Date

December 31, 2025

Study Completion Date

June 30, 2026

Conditions
Chemotherapy;Advanced Gastric Cancer;Cisplatin;Disulfiram
Interventions
DRUG

disulfiram and cisplatin

on the first day of treatment, patients were given intravenous drip of 80mg/m2 cisplatin, and 21 days was a course of treatment, lasting for 6 courses. Take 400mg disulfiram orally every day, and continue to use it until the end of chemotherapy. According to the patient's tolerance to disulfiram, the dose of disulfiram can be re-evaluated during the treatment, and the lowest dose is 125mg per day. The clinical symptoms, signs and adverse reactions of patients were observed, and the treatment effect of patients was evaluated after two consecutive cycles with 3 weeks as a cycle.

DRUG

cisplatin

on the first day of treatment, patients were given 80mg/m2 cisplatin intravenously, and 21 days was a course of treatment, lasting for 6 courses.

Trial Locations (1)

310000

Hangzhou first people's Hospital, Hangzhou

All Listed Sponsors
collaborator

College of Pharmaceutical Sciences at Zhejiang University

UNKNOWN

collaborator

The Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University

UNKNOWN

lead

First People's Hospital of Hangzhou

OTHER

NCT05667415 - Treatment of Advance Gastric Cancer With Disulfiram | Biotech Hunter | Biotech Hunter