119
Participants
Start Date
February 9, 2023
Primary Completion Date
September 18, 2025
Study Completion Date
November 17, 2025
Recombinant humanized anti-BTLA monoclonal antibody (JS004) injection
200mg via IV infusion once every 3 weeks;JS004 will be administered in combination with toripalimab until disease progression or intolerable toxicity or up to 2 years of treatment or other reasons specified in the protocol
Toripalimab
240mg via IV infusion once every 3 weeks;JS004 will be administered in combination with toripalimab until disease progression or intolerable toxicity or up to 2 years of treatment or other reasons specified in the protocol
Docetaxel
60 or 75mg/m2 via IV infusion on Day 1 of a 21-day cycle, which may be maintained until disease progression
Pemetrexed
500mg/m2 via IV infusion on Day 1 of a 21-day cycle for 4 cycles; Subjects who have disease progression after 4 cycles may continue to receive maintenance treatment with pemetrexed
Cisplatin
75mg/m2 via IV infusion on Day 1 of a 21-day cycle for 4 cycles
Carboplatin
AUC 5 via IV infusion on Day 1 of a 21-day cycle for 4 cycles
Paclitaxel
175mg/m2 via IV infusion on Day 1 of a 21-day cycle for 4 cycles
Etoposide
100mg/m2 via IV infusion on Days 1, 2, and 3 of a 21-day cycle for 4 cycles
Shanghai Chest Hospital, Shanghai
Shanghai Junshi Bioscience Co., Ltd.
OTHER