A Clinical Study of VA-CAG as Induction Therapy in Newly Diagnosed AML Patients

PHASE2CompletedINTERVENTIONAL
Enrollment

114

Participants

Timeline

Start Date

December 1, 2022

Primary Completion Date

December 30, 2024

Study Completion Date

April 30, 2025

Conditions
Acute Myeloid Leukemia
Interventions
DRUG

Venetoclax in combination with azacitidine and CAG

"Induction:~VA regimen:~Drug: Venetoclax orally once daily (100 mg d1, 200 mg d2, 400 mg d3-21);~Drug: Azacitidine 75 mg/m2 subcutaneously once daily on days 1-7.~CAG regimen:~Drug: Cytarabine 10mg/m2 subcutaneously q12h on days 1-7;~Drug: Aclacinomycin 12-14mg/m2 on days 1,3,5,7;~Drug: Granulocyte colony-stimulating factor 5ug/kg on days 0-8, discontinue if WBC \>20×10\^9/L;~Consolidation:~Drug: Cytarabine 3g/m2 q12h on days 1-3."

Trial Locations (1)

650000

920th Hospital of Joint Logistics Support Force of People's Liberation Army of China, Kunming

All Listed Sponsors
lead

Hematology department of the 920th hospital

OTHER