A Multiple Dose Study to Investigate Safety, Tolerability and Pharmacokinetics of MN-08 Tablets

PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

16

Participants

Timeline

Start Date

September 1, 2025

Primary Completion Date

March 30, 2026

Study Completion Date

June 1, 2026

Conditions
Pulmonary Arterial Hypertension
Interventions
DRUG

MN-08 24 mg/day

Subjects in this cohort will receive 12 mg MN-08 tablets b.i.d. for a total daily dose of 24 mg or matching placebo for 6 consecutive days, and the last dose (12 mg) on the morning of Day 7.

DRUG

MN-08 60 mg/day

Subjects in this cohort will receive 30 mg MN-08 tablets b.i.d. for a total daily dose of 60 mg or matching placebo tablets for 6 consecutive days, and the last dose (30 mg) on the morning of Day 7.

All Listed Sponsors
lead

Guangzhou Magpie Pharmaceuticals Co., Ltd.

INDUSTRY