RNA Lipid Particles Targeting Pediatric Recurrent Intracranial Malignancies and Other systEmic Solid Tumors

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

36

Participants

Timeline

Start Date

March 12, 2025

Primary Completion Date

October 31, 2033

Study Completion Date

October 31, 2035

Conditions
Recurrent Pulmonary OsteosarcomaRecurrent High-grade Glioma
Interventions
BIOLOGICAL

pp65 RNA LP (DP1)

This is an off the shelf RNA-LP vaccine used to prime for the immune response while we produce the patient specific pp65/tumor mRNA RNA-LP (DP2)

BIOLOGICAL

pp65/tumor mRNA RNA-LP (DP2)

This is a patient specific RNA-LP vaccine generated from the patient's tumor RNA.

PROCEDURE

Surgical Biopsy/Resection

Eligible participants will be enrolled and undergo sterile collection of tumor material .

Trial Locations (1)

32608

RECRUITING

UF Health, Gainesville

All Listed Sponsors
collaborator

The V Foundation for Cancer Research

OTHER

collaborator

National Pediatric Cancer Foundation

OTHER

collaborator

Alex's Lemonade Stand Foundation

INDUSTRY

collaborator

The Osteosarcoma Institute

UNKNOWN

collaborator

National Cancer Institute (NCI)

NIH

lead

University of Florida

OTHER