Reducing Acute Upper Gastrointestinal Side-Effects of Thoracic Irradiation

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

142

Participants

Timeline

Start Date

December 13, 2022

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2026

Conditions
Radiation Esophagitis
Interventions
DRUG

Sucralfate

"1. Sucralfate, 1 gram/10 mL oral suspension By mouth, take 10 mL twice a day until RT completion, with one dose 30-60 minutes prior to their midday meal and the second dose prior to bedtime.May increase frequency up to 4 times per day, per physician discretion. Or~2. Sucralfate 1 gram tablets By mouth, take one (1) tablet mixed in 15-30 mL warm water twice a day until RT completion, with one dose 30-60 minutes prior to their midday meal and the second dose prior to bedtime.~The frequency of sucralfate can be adjusted at anytime at the treating physician's discretion after the patient has started it at twice a day, and the patient may discontinue sucralfate at anytime after RT completion, per physician discretion. May increase frequency up to 4 times per day, per physician discretion."

OTHER

Usual Care

Standard supportive care by using opioids.

OTHER

One consent

Patient will sign one consent form.

OTHER

Two consent

Patient will sign two consent forms.

Trial Locations (7)

10065

Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York

10604

Memorial Sloan Kettering Westchester (All Protocol Activities), Harrison

11553

Memorial Sloan Kettering Nassau (All Protocol Activities), Uniondale

11725

Memorial Sloan Kettering Suffolk-Commack (All Protocol Activities ), Commack

07920

Memorial Sloan Kettering Cancer Center Basking Ridge (All Protocol Activities), Basking Ridge

07748

Memorial Sloan Kettering Monmouth (All Protocol Activities), Middletown

07645

Memorial Sloan Kettering Bergen (All Protocol Activities), Montvale

All Listed Sponsors
lead

Memorial Sloan Kettering Cancer Center

OTHER