Renal Retention in High Grade Upper Tract Urothelial Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

November 25, 2024

Primary Completion Date

June 30, 2028

Study Completion Date

June 30, 2029

Conditions
High Grade Urothelial CarcinomaBladder CancerUrothelial Carcinoma Bladder
Interventions
DRUG

Enfortumab vedotin

Enfortumab vedotin 1.25mg/kg on Days 1 and 8 every 3 weeks for up to 35 weeks (each cycle = 21 days)

DRUG

Pembrolizumab

Pembrolizumab 200mg on Day 1 every 3 weeks for up to 35 weeks (each cycle = 21 days)

Trial Locations (2)

20016

RECRUITING

Johns Hopkins University: Sibley Memorial Hospital, Washington D.C.

21287

RECRUITING

Johns Hopkins University: Sidney Kimmel Comprehensive Cancer Center, Baltimore

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Astellas Pharma Inc

INDUSTRY

collaborator

Seagen Inc.

INDUSTRY

collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

OTHER

NCT05656235 - Renal Retention in High Grade Upper Tract Urothelial Cancer | Biotech Hunter | Biotech Hunter