TAS-116 Plus Palbociclib in Breast and Rb-null Cancer

PHASE1WithdrawnINTERVENTIONAL
0
Timeline

Start Date

September 12, 2023

Primary Completion Date

August 5, 2024

Study Completion Date

August 5, 2024

Conditions
Advanced Breast CancerTreatment-Refractory Solid TumorsRetinoblastoma DeficiencySCLCSoft Tissue SarcomaEndometrial CancerBladder Cancer
Interventions
DRUG

Palbociclib Oral Product

125 mg/day (FDA approved dose) or the last tolerated dose before progression for 21 days of a 28-day cycle

DRUG

TAS-116

120 mg/day, 5 days on 2 days off, for days 1-28 of a 28 day cycle

DRUG

TAS-116

80 mg/day, 5 days on 2 days off, for days 1-28 of a 28 day cycle

DRUG

TAS-116

40 mg/day, 5 days on 2 days off, for days 1-28 of a 28 day cycle

Trial Locations (1)

02903

Lifespan Cancer Institute, Providence

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Brown University

OTHER

NCT05655598 - TAS-116 Plus Palbociclib in Breast and Rb-null Cancer | Biotech Hunter | Biotech Hunter