Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity

NARecruitingINTERVENTIONAL
Enrollment

144

Participants

Timeline

Start Date

June 18, 2024

Primary Completion Date

February 1, 2027

Study Completion Date

February 1, 2027

Conditions
Mild Cognitive ImpairmentChronic Kidney Diseases
Interventions
BEHAVIORAL

Home-based walking exercise

A 6-month partially supervised walking exercise program using a tapered approach.Participants will begin exercise (walking) at a relatively low intensity and progress to moderate intensity. Intensity will start at 40% and progress as tolerated up to 60-70%. Rating of perceived exertion of 12-14 (fairly light to moderate) will be used to aid intensity (Rating of perceived exertion 6-20 scale). This is an accepted method for achieving desired exercise intensity. Participants will progress over time to exercise 3-4/week for 30-45 minutes. The exercise program may need to be adjusted for (e.g. 10 minutes of exercise 3 times), to achieve the minimum exercise dose of 30 minutes. This will be determined for each individual participants as needed.

OTHER

Attention control

Health education and stretching

Trial Locations (1)

10023

RECRUITING

Columbia University, New York

All Listed Sponsors
collaborator

National Institute on Aging (NIA)

NIH

lead

Columbia University

OTHER