Conversion of Maintenance Prograf to Envarsus in Liver Transplant Recipients

PHASE4Enrolling by invitationINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

January 1, 2024

Primary Completion Date

April 30, 2025

Study Completion Date

February 28, 2026

Conditions
Liver Transplant RejectionImmune System Suppression
Interventions
DRUG

Prograf

Participants randomized to the Prograf (control) arm will continue with their current twice daily dosing of Prograf.

DRUG

Envarsus

Participants randomized to Envarsus arm will have their current daily dose of Prograf converted to once-daily Envarsus dose according to the following ratio: 0.7 x the current daily Prograf dose. Envarsus is available in 3 dose strengths- 0.75mg, 1.0mg, and 4.0mg. The actual dose of Envarsus will be rounded to an amount that can be administered using the above tablet strengths.

Trial Locations (1)

M5G2N2

Toronto General Hospital, Toronto

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Paladin Labs Inc.

OTHER

lead

University Health Network, Toronto

OTHER

NCT05655273 - Conversion of Maintenance Prograf to Envarsus in Liver Transplant Recipients | Biotech Hunter | Biotech Hunter