Study Comparing Two Methods for the Treatment of Large Chondral and Osteochondral Defects of the Knee

NANot yet recruitingINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

June 1, 2023

Primary Completion Date

June 1, 2028

Study Completion Date

June 1, 2032

Conditions
Articular Cartilage DefectChondral DefectOsteochondritis
Interventions
PROCEDURE

MACT

"* A biopsy of healthy cartilage is taken from a non-weight bearing area of the knee joint during an arthroscopic procedure.~* The biopsy is processed in the GMP accredited laboratory to isolate and amplify chondrocytes.~* The cells are seeded and cultured on a collagen matrix (Chondro-Gide®, Geistlich Pharma)~* The membrane is implanted and sutured onto the injured site."

PROCEDURE

AMT

This treatment combines the microfracture procedure with the application of a bilayer matrix of porcine type I/III collagen (Chondro-Gide, Geistlich Pharma) and the supplementation of autologous bone.

Trial Locations (2)

1011

Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne

1708

Hôpital Fribourgeois- HFR, Fribourg

All Listed Sponsors
collaborator

Lee Ann LAURENT APPLEGATE

UNKNOWN

collaborator

Virginie PHILIPPE

UNKNOWN

lead

Centre Hospitalier Universitaire Vaudois

OTHER

NCT05651997 - Study Comparing Two Methods for the Treatment of Large Chondral and Osteochondral Defects of the Knee | Biotech Hunter | Biotech Hunter