Zanubrutinib and Venetoclax as Initial Therapy for Chronic Lymphocytic Leukemia (CLL) With Response-based Obinutuzumab

PHASE2RecruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

May 8, 2023

Primary Completion Date

March 31, 2027

Study Completion Date

December 31, 2027

Conditions
Leukemia, Lymphocytic, Chronic, B-Cell
Interventions
DRUG

Zanubrutinib Pill

320 mg once per day by mouth

DRUG

Venetoclax Pill

400 mg once per day by mouth following the standard ramp-up schedule (20mg daily PO week 1, 50mg daily PO week 2, 100mg daily PO week 3, 200mg daily PO week 4, followed by 400mg PO daily week 5)

DRUG

Obinutuzumab Injection

1000 mg IV given every 28 days

Trial Locations (1)

10021

RECRUITING

Weill Cornell Medicine/NewYork-Presberteryian Hospital, New York

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

BeiGene

INDUSTRY

collaborator

Genentech, Inc.

INDUSTRY

lead

Weill Medical College of Cornell University

OTHER