Sleep Impairment in Subjects at Risk of Developing Alzheimer's Disease

Polysomnography will be performed for 24 hours at inclusion and 24 months

A full neuropsychological assessment will be performed at inclusion, 12 and 24 months

Questionnaires on sleep and behavioural problems

Measurement of actimetrics for 14 days at inclusion and at 24 months

Determination of the biomarkers Aβ42, Aβ40, Tau and P-Tau in blood and in the cerebrospinal fluid