512
Participants
Start Date
January 4, 2023
Primary Completion Date
October 28, 2024
Study Completion Date
December 13, 2024
Semaglutide
Participants will receive once-weekly s.c. injections of semaglutide in escalating doses (0.25 mg, 0.5 mg, 1.0 mg, 1.7 mg, 2.4 mg and 7.2 mg) every fourth week. Treatment will be continued on the maintenance dose of 7.2 mg once-weekly for an additional 52 weeks. Injections may be administered in the thigh, abdomen, or upper arm, at any time of day irrespective of meals.
Semaglutide
Participants will receive once-weekly s.c. injections of semaglutide in escalating doses (0.25 mg, 0.5 mg, 1.0 mg, 1.7 mg, and 2.4 mg) every fourth week. Treatment will be continued on the maintenance dose of 2.4 mg once-weekly for an additional 52 weeks. Injections may be administered in the thigh, abdomen, or upper arm, at any time of day irrespective of meals.
Placebo
Participants will receive once-weekly s.c. injection of placebo matched to semaglutide for 72 weeks. Injections may be administered in the thigh, abdomen, or upper arm, at any time of day irrespective of meals.
ClinDiab Egészségügyi Szolgáltató és Kereskedelmi Kft., Budapest
Bajcsy-Zsilinszky Kórház, Budapest
MED-TIMA Kft., Budapest
DCC VII - Sofia EOOD, Endocrinology, Sofia
Deepak Lakha, Johannesburg
Hemant Makan, Johannesburg
Wits Bara Clinical Trial Site, Johannesburg
"MHAT-Blagoevgrad, Department of Internal Diseases", Blagoevgrad
Maxwell Centre, Durban
'MHAT Sveta Karidad' EAD, Plovdiv
Belinus Bt., Debrecen
Dr N.K. Gounden Medical Centre, Durban
Dr T Padayachee, eMkhomazi
UMHAT Pulmed, Department of endocrinology, Pazardzhik
Borbánya Praxis E.Ü. Kft., Nyíregyháza
Lenmed Shifa Private Hospital, Durban
Phoenix Pharma, Port Elizabeth
"UMHAT- Prof. dr. Stoyan Kirkovich", Stara Zagora
Lausmed Kft., Baja
IPSOMC - Dr. Georgi Marinov, Burgas
Fejér Megyei Szent György Oktatókórház, Székesfehérvár
"MHAT Sveti Panteleimon - Yambol AD", Yambol
'MHAT Hadzhi Dimitar' OOD, Sliven
"Medical Center Viva Feniks Ood", Dobrich
Medi-Clinic Bloemfontein, Bloemfontein
National Clin Res Inc., Richmond
PharmQuest Life Sciences LLC, Greensboro
University of North Carolina, Chapel Hill
Hope Clin Res & Wellness, Conyers
Jacksonville Ctr for Clin Res, Jacksonville
ARS- Deland CRU, DeLand
Oviedo Medical Research, LLC, Oviedo
Florida Inst For Clin Res LLC, Orlando
Univ of Alabama Birmingham, Birmingham
Velocity Clin Res, Dallas, Dallas
UT Southwestern Medical Center - Lingvay, Dallas
DCOL Ctr for Clin Res, Longview
PlanIt Research, PLLC, Houston
Sugar Lakes Family Practice PA, Sugar Land
Elligo Clin Res Centre, Austin
Amarillo Med Spec LLP, Amarillo
New West Physicians PC, Golden
Velocity Clinical Research Westlake, Los Angeles
John Muir Physicians Network, Concord
Diablo Clinical Research, Inc., Walnut Creek
Selma Medical Associates, Winchester
Ocean West Research Clinic, Surrey
G.A. Research Associates Ltd., Moncton
Nova Scotia Hlth Halifax, Halifax
Premier Clinical Trial Research Network (PCTRN), Hamilton
Wharton Med Clin Trials, Hamilton
Milestone Research, London
Med. Cent. Diabet. Endo. Metabol. DIAB-ENDO-MET, Krakow
NZOZ Przychodnia Specjalistyczna Medica, Lublin
"NZOZ CenterMed Lublin Sp. z o.o.", Lublin
Kresmed Sp. z o. o., Bialystok
Uniwersyteckie Centrum Kliniczne SUM w Katowicach, Katowice
NBR Polska Tomasz Klodawski, Warsaw
PANSTWOWY INSTYTUT MEDYCZNY MSWiA, Warsaw
Unidade Local De Saude De Matosinhos E.P.E., Senhora Da Hora, Matosinhos
APDP - Associação Protectora dos Diabéticos de Portugal, Lisbon
Unidade Local de Saude de Sao Joao E.P.E, Porto
DIADA s.r.o., Bardejov
DIADA, s.r.o., Bardejov
Diab - Int, s.r.o., Bytča
ENDOMED, s.r.o., Košice
MED-DIA CENTRUM s.r.o., Považská Bystrica
DIABETOL, s.r.o., Prešov
Lead Sponsor
Novo Nordisk A/S
INDUSTRY