SPEARHEAD-3 Pediatric Study

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

September 1, 2023

Primary Completion Date

October 1, 2026

Study Completion Date

July 30, 2038

Conditions
Synovial SarcomaMalignant Peripheral Nerve Sheath Tumor (MPNST)Neuroblastoma (NBL)Osteosarcoma
Interventions
GENETIC

Afamitresgene autoleucel

Single infusion of afamitresgene autoleucel Dose: For subjects ≥10 kg to \<40 kg: starting dose of 0.025 - 0.200 x 10'9 transduced cells/kg. For subjects ≥40 kg 1.0x109 to 10x109 transduced by a single intravenous infusion

Trial Locations (10)

10065

NOT_YET_RECRUITING

Dana Farber Cancer Institute, Boston

NOT_YET_RECRUITING

Memorial Sloan Kettering Kids, New York

19104

RECRUITING

Children's Hospital of Philedephia, Philadelphia

20892

RECRUITING

National Institutes of Health, Bethesda

27710

NOT_YET_RECRUITING

Duke University School of Medicine, Durham

45229

RECRUITING

Cincinnati Children's Hospital Medical Center, Cincinnati

53715

RECRUITING

University of Wisconsin Cancer Center, Madison

63110

RECRUITING

Washington University, St Louis

94305

RECRUITING

Stanford University, Palo Alto

98105

NOT_YET_RECRUITING

Seattle Children's Hospital, Seattle

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Adaptimmune

INDUSTRY

NCT05642455 - SPEARHEAD-3 Pediatric Study | Biotech Hunter | Biotech Hunter