Brivaracetam to Reduce Neuropathic Pain in Chronic SCI: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

PHASE3CompletedINTERVENTIONAL
Enrollment

44

Participants

Timeline

Start Date

January 1, 2023

Primary Completion Date

October 7, 2024

Study Completion Date

October 16, 2024

Conditions
Spinal Cord InjuriesNeuropathic Pain
Interventions
DRUG

brivaracetam

Drug dosage will be individually titrated for each participant with a goal of 100mg BID according to the following dose escalation protocol that we use clinically: 50mg BID for 2 weeks, followed by 50mg TID for 2 weeks, followed by 100mg BID for 48 days as tolerated. Participants will be allowed to reduce the dose of brivaracetam if they experience unacceptable side effects defined as increased somnolence according to routine clinical practice with other drugs in this class used for pain.

DRUG

Placebo

Participants will receive placebo drug

Trial Locations (1)

55455

University of Minnesota, Minneapolis

All Listed Sponsors
lead

University of Minnesota

OTHER