Novel Anti-CD19 Universal CAR-T Cells for r/r CD19+ B-ALL

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

December 5, 2022

Primary Completion Date

December 31, 2024

Study Completion Date

December 31, 2025

Conditions
B-cell Acute Lymphoblastic LeukemiaB-ALL
Interventions
BIOLOGICAL

UCAR-T Cells

"UCAR-T Cellswill be administered by vein. The trial includes two portions. The first portion is a3+3dose escalation study, in which three dose groups are set:Dose level one:1×10\^6 cells/kg;Dose level two:2×10\^6 cells/kg;Dose level three:5×10\^6 cells/kg. Each dose group requires at least three subjects. The trial will start from dose level one. The second portion includes a dosage extended cohort and will start after the finish of the3+3dose escalation study. Twelve subjects will get infusion of UCAR-T Cells at the best dose verified in the first portion."

Trial Locations (1)

650000

RECRUITING

920th Hospital of Joint Logistics Support Force of People's Liberation Army of China, Kunming

All Listed Sponsors
lead

920th Hospital of Joint Logistics Support Force of People's Liberation Army of China

OTHER