Trauma Resuscitation With Low-Titer Group O Whole Blood or Products

PHASE3RecruitingINTERVENTIONAL
Enrollment

1,100

Participants

Timeline

Start Date

July 27, 2023

Primary Completion Date

December 31, 2026

Study Completion Date

June 30, 2027

Conditions
Wounds and InjuriesShock, Hemorrhagic
Interventions
BIOLOGICAL

LTOWB

Participants will receive Low Titer O Whole Blood administered intravenously or intraosseously.

BIOLOGICAL

Components

Participants will receive separated blood components (i.e., units of red cells, plasma, platelets, and cryoprecipitate) co-administered intravenously or intraosseously.

Trial Locations (13)

19104

NOT_YET_RECRUITING

Penn Presbyterian Medical Center, Philadelphia

21201

NOT_YET_RECRUITING

University of Maryland Medical Center, Baltimore

27157

NOT_YET_RECRUITING

Atrium Health Wake Forest Baptist, Winston-Salem

35294

RECRUITING

University of Alabama at Birmingham, UAB Hospital, Birmingham

45267

RECRUITING

University of Cincinnati Medical Center, Cincinnati

53226

NOT_YET_RECRUITING

Froedtert Hospital, Milwaukee

63110

NOT_YET_RECRUITING

Washington University School of Medicine, St Louis

70112

NOT_YET_RECRUITING

University Medical Center New Orleans LCMC Health, New Orleans

77030

NOT_YET_RECRUITING

University of Texas Health Science Center Houston, Houston

78229

NOT_YET_RECRUITING

University of Texas Health San Antonio and University Health System, San Antonio

90033

NOT_YET_RECRUITING

Los Angeles County + University of Southern California (LAC + USC) Medical Center, Los Angeles

97239

NOT_YET_RECRUITING

Oregon Health and Sciences University Hospital, Portland

98104

RECRUITING

Harborview Medical Center, Seattle

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

The University of Texas Health Science Center, Houston

OTHER

lead

University of Alabama at Birmingham

OTHER