Safety and Immunogenicity of Recombinant Herpes Zoster Vaccine (CHO Cells) in Healthy Subjects Aged 18 Years and Above

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

132

Participants

Timeline

Start Date

December 7, 2022

Primary Completion Date

December 30, 2024

Study Completion Date

December 30, 2024

Conditions
Herpes Zoster
Interventions
BIOLOGICAL

Low Dose Recombinant Herpes Zoster Vaccine (CHO cells)

0.5 mL per dose, containing a total of 50 µg recombinant varicella zoster virus glycoprotein E, adjuvanted with low dose MA105.

BIOLOGICAL

High Dose Recombinant Herpes Zoster Vaccine (CHO cells)

0.5 mL per dose, containing a total of 50 µg recombinant varicella zoster virus glycoprotein E, adjuvanted with high dose MA105.

BIOLOGICAL

Low dose adjuvant

0.5 mL per dose, containing low dose MA105 adjuvant.

BIOLOGICAL

High dose adjuvant

0.5 mL per dose, containing high dose MA105 adjuvant.

BIOLOGICAL

Positive control

0.5 mL per dose, containing a total of 50 µg recombinant varicella zoster virus glycoprotein E, adjuvanted with AS01B.

BIOLOGICAL

Placebo

0.5 mL per dose, containing 4.5 mg sodium chloride.

Trial Locations (1)

453200

Yanjin District Center for Disease Control and Prevention, Xinxiang

All Listed Sponsors
collaborator

Henan Center for Disease Control and Prevention

OTHER_GOV

lead

MAXVAX Biotechnology Limited Liability Company

INDUSTRY

NCT05636436 - Safety and Immunogenicity of Recombinant Herpes Zoster Vaccine (CHO Cells) in Healthy Subjects Aged 18 Years and Above | Biotech Hunter | Biotech Hunter