Efficacy and Safety Study of Efgartigimod in Adults With Post-COVID-19 POTS

PHASE2CompletedINTERVENTIONAL
Enrollment

53

Participants

Timeline

Start Date

September 23, 2022

Primary Completion Date

April 18, 2024

Study Completion Date

April 18, 2024

Conditions
Postural Orthostatic Tachycardia Syndrome
Interventions
DRUG

Efgartigimod

Efgartigimod IV 10 mg/kg infusion qw for 24 weeks. Participants will be randomized to receive efgartigimod IV 10 mg/kg or matching placebo in a 2:1 ratio, respectively

DRUG

Placebo

"Receive a matching placebo during weekly infusions during a treatment period of 24 weeks.~Participants will be randomized to receive efgartigimod IV 10 mg/kg or matching placebo in a 2:1 ratio, respectively"

Trial Locations (11)

21224

Johns Hopkins University, Baltimore

37232

Vandetbilt University Medical Center / Clinical Research Center, Nashville

44106

Case Western Reserve University, Cleveland

60026

Northshore University Health System, Glenview

75071

Texas Institute of Cardiology, McKinney

76132

Apex Trials Croup, LLC, Fort Worth

77583

Pioneer Clinical Research, Rosharon

84119

Metrodora Institute, West Valley City

92037

University of California, San Diego Sulpizio Cardiovascular Center, La Jolla

94304

Stanford Movement Disorder Center, Palo Alto

02115

Harvard Medical School, Brigham and Women's Hospital, Boston

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Iqvia Pty Ltd

INDUSTRY

lead

argenx

INDUSTRY

NCT05633407 - Efficacy and Safety Study of Efgartigimod in Adults With Post-COVID-19 POTS | Biotech Hunter | Biotech Hunter