ASKB589 in Combination With CAPOX and PD-1 Inhibitors in Patients With Advanced, and Unresectable G/GEJ Cancer.

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

62

Participants

Timeline

Start Date

February 21, 2023

Primary Completion Date

October 31, 2025

Study Completion Date

February 10, 2026

Conditions
Gastric CancerGastroesophageal Cancer (GC)
Interventions
DRUG

ASKB589 +CAPOX+Sintilimab/Tislelizumab

"Oxaliplatin: intravenous infusion, 130mg/m2, infusion for more than 3h, every 3 weeks for a cycle, infusion 6 cycles; Capecitabine: oral administration, 1000mg/m2, 2 times, 14 days, 7 days rest, every 3 weeks for a cycle; Sintilimab/Tislelizumab was administered intravenously at 200mg. The drug was administered once every 3 weeks, and the longest cumulative duration was 2 years.~ASKB589 is administered intravenously at a fixed dose. The drug was given once every 3 weeks for a cycle, with the longest cumulative duration of 2 years."

Trial Locations (1)

100089

Beijing Cancer Hospital, Beijing

All Listed Sponsors
collaborator

Jiangsu Aosaikang Pharmaceutical Co., Ltd.

INDUSTRY

lead

AskGene Pharma, Inc.

INDUSTRY