TRAC Locus-inserted CD19-targeting STAR-T Cell Therapy in r/r B-NHL

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

38

Participants

Timeline

Start Date

June 30, 2023

Primary Completion Date

December 15, 2024

Study Completion Date

December 15, 2025

Conditions
Non-hodgkin Lymphoma,B Cell
Interventions
BIOLOGICAL

Autologous CD19-STAR-T cell

Phase 1 dose escalation (3+3) : dose 1 (1×10\^6 cells/kg) ,dose 2 (3×10\^6 cells/kg) ,dose 3 (1×10\^7 cells/kg); Phase 2 : Appropriate dose

DRUG

Fludarabine

Intravenous fludarabine 25-30 mg/m\^2/day on days -5, -4, and -3.

DRUG

Cyclophosphamide

Intravenous cyclophosphamide 300-500 mg/m\^2/day on days -5, -4, and -3.

Trial Locations (2)

100853

RECRUITING

Biotherapeutic Department, Chinese PLA General Hospital, Beijing

Unknown

RECRUITING

School of medicine, Tsinghua University & Changping Laboratory, Beijing

All Listed Sponsors
lead

Chinese PLA General Hospital

OTHER