Drug-drug Interaction Study Beteewn ASK120067 and Rifampicin or Itraconazole

PHASE1CompletedINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

June 6, 2022

Primary Completion Date

August 3, 2022

Study Completion Date

August 3, 2022

Conditions
Locally Advanced or Metastatic NSCLC
Interventions
DRUG

Rifampicin; ASK120067

Take ASK120067 tablets orally once on the first day at 160mg in fast condition;Take rifampicin capsules orally once on the days 8 to 17 at 600mg in fast condition, and a combination of 160mg ASk120067 and 600mg rifampicin were administrated on the 15th day in fast condition.

DRUG

ASK120067;itraconazole

Take ASK120067 tablets orally once on the first day at 80mg in fast condition;Take itraconazole capsules orally twice on the days 8 to 13 at 200mg in fed condition, and a combination of 80mg ASK120067 and 200mg itraconazole were administrated on the 11th day in fast condition.

Trial Locations (1)

Unknown

Drum Tower Hospital of Nanjing University School of Medical, Nanjing

All Listed Sponsors
lead

Jiangsu Aosaikang Pharmaceutical Co., Ltd.

INDUSTRY