Study of Covalent Menin Inhibitor BMF-219 in Adult Patients With KRAS Driven Non-Small Cell Lung Cancer, Pancreatic Cancer, and Colorectal Cancer

PHASE1TerminatedINTERVENTIONAL
Enrollment

13

Participants

Timeline

Start Date

January 12, 2023

Primary Completion Date

January 15, 2025

Study Completion Date

January 15, 2025

Conditions
Non Small Cell Lung CancerPancreatic CancerColorectal CancerNSCLCPDACCRCRelapsed CancerRefractory CancerStage III Pancreatic CancerStage IV Pancreatic CancerStage III Non-small Cell Lung CancerStage IV Non-small Cell Lung CancerStage III Colorectal CancerStage IV Colorectal CancerStage III NSCLCStage IV NSCLCKRAS Mutation-Related Tumors
Interventions
DRUG

BMF-219

BMF-219 is an orally bioavailable, covalent small-molecule menin inhibitor.

Trial Locations (23)

14263

Roswell Park Cancer Institute, Buffalo

22031

NEXT Virginia, Fairfax

30269

Cancer Treatment Centers of America - Atlanta, Atlanta

33140

Mount Sinai Comprehensive Cancer Center, Miami Beach

37203

Tennessee Oncology, Nashville

37232

Vanderbilt Ingram Cancer Center, Nashville

43210

Ohio State University, Columbus

55905

Mayo Clinic, Rochester

60099

Cancer Treatment Centers of America - Chicago, Zion

60611

Robert H. Lurie Comprehensive Cancer Center of Northwestern Univeristy, Chicago

63110

Washington University School of Medicine - Siteman Cancer Center, St Louis

68198

University of Nebraska Medical Center, Omaha

77030

The University of Texas MD Anderson Cancer Center, Houston

78229

NEXT Oncology, San Antonio

80237

Sarah Cannon Research Institute at HealthONE, Denver

85338

Cancer Treatment Centers of America - Phoenix, Goodyear

92024

California Cancer Associates for Research and Excellence (cCARE), Encinitas

92037

University of California, San Diego, La Jolla

98109

Fred Hutchinson Cancer Center, Seattle

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital Yonsei University Health System - PPDS, Seoul

06351

Samsung Medical Center, Seoul

Unknown

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Biomea Fusion Inc.

INDUSTRY

NCT05631574 - Study of Covalent Menin Inhibitor BMF-219 in Adult Patients With KRAS Driven Non-Small Cell Lung Cancer, Pancreatic Cancer, and Colorectal Cancer | Biotech Hunter | Biotech Hunter