A Study to Evaluate the Effects of Cenicriviroc Mesylate on Arterial Inflammation in People Living With HIV

PHASE2CompletedINTERVENTIONAL
Enrollment

110

Participants

Timeline

Start Date

May 30, 2023

Primary Completion Date

June 19, 2024

Study Completion Date

June 19, 2024

Conditions
HIV-1-infectionElevated Cardiovascular Risk
Interventions
DRUG

CVC 150 mg

Administered as one 150-mg tablet by mouth once a day with food.

DRUG

CVC 300 mg

Administered as two 150-mg tablets by mouth once a day with food.

OTHER

Placebo for CVC 150 mg

Administered as one 150-mg matching placebo tablets by mouth once a day with food.

OTHER

Placebo for CVC 300 mg

Administered as two 150-mg matching placebo tablets by mouth once a day with food.

Trial Locations (19)

10010

Weill Cornell Chelsea CRS (Site # 7804), New York

10065

Weill Cornell Uptown CRS (Site # 7803), New York

14642

University of Rochester Adult HIV Therapeutic Strategies Network CRS (Site # 31787), Rochester

15213

University of Pittsburgh CRS (Site # 1001), Pittsburgh

37204

Vanderbilt Therapeutics (VT) CRS (Site # 3652), Nashville

44106

Case CRS (Site # 2501), Cleveland

60611

Northwestern University CRS (Site # 2701), Chicago

77030

Houston AIDS Research Team CRS (Site # 31473), Houston

90035

University of California, Los Angeles CARE Center CRS (Site # 601), Los Angeles

90502

Harbor University of California Los Angeles Center CRS (Site # 603), Torrance

92103

UCSD Antiviral Research Center CRS (Site # 701), San Diego

94110

UCSF HIV/AIDS CRS (Site # 801), San Francisco

98104

University of Washington Positive Research CRS (Site # 1401), Seattle

02114

Massachusetts General Hospital CRS (MGH CRS) (Site # 101), Boston

02115

Brigham and Women's Hospital Therapeutics (BWH TCRS) CRS (Site # 107), Boston

63110-1010

Washington University Therapeutics (WT) CRS (Site # 2101), St Louis

27599-7215

Chapel Hill CRS (Site # 3201), Chapel Hill

45267-0405

Cincinnati CRS (Site # 2401), Cincinnati

43210-1282

Ohio State University CRS (Site # 2301), Columbus

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

AbbVie

INDUSTRY

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH