A Study to Compare Bioavailability of AZD5055 Film-coated Tablet With AZD5055 Oral Suspension and to Assess the Effect of Food and an Acid Reducing Agent on Pharmacokinetics (PK) of AZD5055 in Healthy Subjects.

PHASE1CompletedINTERVENTIONAL
Enrollment

21

Participants

Timeline

Start Date

November 4, 2022

Primary Completion Date

February 9, 2023

Study Completion Date

February 9, 2023

Conditions
Healthy Volunteers
Interventions
DRUG

AZD5055 solution for infusion

Subjects will receive a single dose intravenous infusion of AZD5055 as 20-minute infusion on Day 1 of the respective period in overnight fasted state.

DRUG

AZD5055 oral suspension

Subjects will receive single dose of AZD5055 oral suspension on Day 1 of the respective period in overnight fasted state.

DRUG

AZD5055 film-coated tablet

Subjects will receive single oral dose of AZD5055 film-coated tablets on Day 1 of the respective period in overnight fasted state.

DRUG

AZD5055 film-coated tablet

Subjects will receive single oral dose of AZD5055 film-coated tablets on Day 1 of the respective period in fed state (either a high fat meal or low-fat meal calorie standard breakfast)

DRUG

Rabeprazole, Delayed-release tablet

Subjects will receive oral doses of rabeprazole twice daily 3 days prior to AZD5055 single dose and 4 days after the AZD5055 single dose including the day that AZD5055 is dosed under fasted conditions \[Study Day 10 to 18\].

DRUG

Rabeprazole, Delayed-release tablet

Subjects will receive oral doses of rabeprazole twice daily prior to AZD5055 single dose under fed conditions (low-fat standard breakfast) and then continued for 2 days.

Trial Locations (1)

21225

Research Site, Brooklyn

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Parexel

INDUSTRY

lead

AstraZeneca

INDUSTRY