21
Participants
Start Date
November 4, 2022
Primary Completion Date
February 9, 2023
Study Completion Date
February 9, 2023
AZD5055 solution for infusion
Subjects will receive a single dose intravenous infusion of AZD5055 as 20-minute infusion on Day 1 of the respective period in overnight fasted state.
AZD5055 oral suspension
Subjects will receive single dose of AZD5055 oral suspension on Day 1 of the respective period in overnight fasted state.
AZD5055 film-coated tablet
Subjects will receive single oral dose of AZD5055 film-coated tablets on Day 1 of the respective period in overnight fasted state.
AZD5055 film-coated tablet
Subjects will receive single oral dose of AZD5055 film-coated tablets on Day 1 of the respective period in fed state (either a high fat meal or low-fat meal calorie standard breakfast)
Rabeprazole, Delayed-release tablet
Subjects will receive oral doses of rabeprazole twice daily 3 days prior to AZD5055 single dose and 4 days after the AZD5055 single dose including the day that AZD5055 is dosed under fasted conditions \[Study Day 10 to 18\].
Rabeprazole, Delayed-release tablet
Subjects will receive oral doses of rabeprazole twice daily prior to AZD5055 single dose under fed conditions (low-fat standard breakfast) and then continued for 2 days.
Research Site, Brooklyn
Lead Sponsor
Collaborators (1)
Parexel
INDUSTRY
AstraZeneca
INDUSTRY