Proton Beam Radiotherapy Followed by Tecentriq and Avastin for Primary Liver Cancer With Vp2-4 Portal Vein Invasion

PHASE2RecruitingINTERVENTIONAL
Enrollment

63

Participants

Timeline

Start Date

January 15, 2023

Primary Completion Date

November 30, 2025

Study Completion Date

November 30, 2026

Conditions
Hepatocellular CarcinomaPortal Vein Thrombosis
Interventions
RADIATION

PBT and atezolizumab/bevacizumab

"Atezolizumab 1200 mg and bevacizumab 15 mg/Kg is administered IV infusion every 3 weeks.~Proton beam therapy 30 - 50 Gy/5 fractions to portal vein tumor thrombosis with or without main primary tumor after 1 week (+/- 7 days) of 2nd cycle of atezolizumab and bevacizumab~The follow-up phase begins when the decision to discontinue study is made. The follow-up phase is defined as the day after the end of study treatment until the day the subject dies."

Trial Locations (1)

06351

RECRUITING

Samsung Medical Center, Seoul

All Listed Sponsors
lead

Samsung Medical Center

OTHER