Pembrolizumab and Olaparib Treatment of Extensive Small Cell Lung Cancer (ES-SCLC)

PHASE2RecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

March 27, 2023

Primary Completion Date

July 31, 2027

Study Completion Date

July 31, 2027

Conditions
SCLC,Extensive Stage
Interventions
DRUG

Pembrolizumab/Olaparib

Patients will receive pembrolizumab 200 mg 1q21 and chemotherapy -platinum compound (cisplatin 75 mg/m2 or carboplatin area under the curve of 5 mg per milliliter per minute) 1q21 plus etoposide 100 mg/m2 1-3q21- for 4 cycles (Induction Phase). In case of responsive or stable disease, patients will receive pembrolizumab 200 mg 1q21 plus olaparib 300 mg twice daily until progression (Maintenance Phase) or up to a maximum of 35 cycles.

Trial Locations (12)

20900

RECRUITING

Ospedale San Gerardo - ASST Monza, Monza

21100

ACTIVE_NOT_RECRUITING

ASST dei Sette Laghi - Osp. di Circolo e Fondazione Macchi, Varese

35128

RECRUITING

Istituto Oncologico Veneto IRCCS, Padua

40138

RECRUITING

UO Oncologia, IRCCS Ospedale Sant'Orsola, AUSL Bologna, Bologna

47014

RECRUITING

UO Oncologia Medica, IRST IRCCS, Meldola

47923

ACTIVE_NOT_RECRUITING

"Azienda USL della Romagna - Osp. Infermi di Rimini", Rimini

48121

ACTIVE_NOT_RECRUITING

Azienda USL della Romagna - Osp. Santa Maria delle Croci, Ravenna

61121

RECRUITING

Azienda Ospedaliera Ospedali Riuniti Marche Nord, Pesaro

70124

RECRUITING

IRCCS Istituto Tumori Giovanni Paolo II, Bari

80131

RECRUITING

"IRCCS Istituto Nazionale Tumori Fondazione G. Pascale", Napoli

Unknown

RECRUITING

A.O. Arcispedale S. Maria Nuova IRCCS di Reggio Emilia, Reggio Emilia

00128

RECRUITING

Istituti Fisioterapici Ospitalieri - IFO -Ospedale Regina Elena, Roma

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS

OTHER