A Study of ALRN-6924 for Protection of Chemotherapy-Induced Side Effects in Patients With TP53-Mutant Breast Cancer

PHASE1TerminatedINTERVENTIONAL
Enrollment

6

Participants

Timeline

Start Date

January 9, 2023

Primary Completion Date

February 22, 2023

Study Completion Date

February 22, 2023

Conditions
Prevention of Chemotherapy-induced Myelosuppression
Interventions
DRUG

ALRN-6924

ALRN-6924 administered in every chemotherapy treatment cycle as an IV infusion over 1 hour on Days 0 (approximately 18 hours prior to chemotherapy administration), 1 (approximately 1 hour prior to chemotherapy administration), and 2 (approximately 24 hours after the second infusion of ALRN-6924).

DRUG

TAC (doxorubicin 50 mg/m2; cyclophosphamide 500 mg/m2; docetaxel 75 mg/m2)

TAC will be administered as an IV infusion on Day 1 of every 3-week treatment cycle

Trial Locations (14)

4000

KOC (Complex Oncology Center) Plovdiv, Plovdiv

4500

MBAL University Hospital OOD, Panagyurishte

11070

"Kliničko bolnički centar Bežanijska kosa", Belgrade

17325

Pennsylvania Cancer Specialists & Resesrach Institute, Gettysburg

21204

Oncology Institute of Vojvodina, Kamenitz

27893

Regional Medical Oncolgy Center, Wilson

28078

Southern Oncology Specialists, Huntersville

33321

Oncology and Hematology Associates of West Broward, Tamarac

34000

Univerzitetski Klinički centar Kragujevac, Kragujevac

44718

Gabrail Cancer Center, Canton

71000

University Clinical Center of the Republic of Srpska, Banja Luka

Clinical Center University of Sarajevo, Oncology Clinic, Sarajevo

75000

University Clinical Center Tuzla, Tuzla

88000

University Clinical Hospital Mostar, Mostar

Sponsors
All Listed Sponsors
lead

Aileron Therapeutics, Inc.

INDUSTRY

NCT05622058 - A Study of ALRN-6924 for Protection of Chemotherapy-Induced Side Effects in Patients With TP53-Mutant Breast Cancer | Biotech Hunter | Biotech Hunter