A Study to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Anti-tumor Activity of RO7616789 in Advanced Small Cell Lung Cancer and Other Neuroendocrine Carcinomas

PHASE1CompletedINTERVENTIONAL
Enrollment

41

Participants

Timeline

Start Date

January 23, 2023

Primary Completion Date

March 4, 2025

Study Completion Date

March 4, 2025

Conditions
Small Cell Lung CancerNeuroendocrine Carcinoma
Interventions
DRUG

RO7616789

RO7616789 solution for infusion will be administered intravenously at a dose and per schedule as specified for the respective part.

DRUG

Tocilizumab

Tocilizumab will be used as rescue therapy, in case of clinical presentation of cytokine release syndrome (CRS). Tocilizumab solution for infusion will be administered intravenously at 8 mg/kg for participants \>/= 30 kg or at 12 mg/kg for participants \< 30 kg.

Trial Locations (17)

2100

Rigshospitalet, København Ø

10065

Memorial Sloan Kettering Cancer Center, New York

15232

University of Pittsburgh Medical Center, Pittsburgh

20007

Georgetown Uni Medical Center, Washington D.C.

28040

Fundacion Jimenez Diaz, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

37203

SCRI Oncology Partners, Nashville

43210

The Ohio State University Comprehensive Cancer Center, Columbus

63110

Washington University School of Medicine, St Louis

02114

Massachusetts General Hospital, Boston

48202-2689

Henry Ford Hospital, Detroit

07601

John Theurer Cancer Center at Hackensack University Medical Center, Hackensack

77030-4009

The University of Texas MD Anderson Cancer Center, Houston

277-8577

National Cancer Center Hospital East, Chiba

104-0045

National Cancer Center Hospital, Tokyo

80-214

Uniwersyteckie Centrum Kliniczne, Gda?sk

08035

Hospital Universitari Vall d'Hebron, Barcelona

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY