A Study Investigating the Efficacy and Safety of LBL-007 Plus Tislelizumab in Combination With Bevacizumab Plus Fluoropyrimidine Versus Bevacizumab Plus Fluoropyrimidine in Participants With Unresectable or Metastatic Colorectal Cancer

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

113

Participants

Timeline

Start Date

January 29, 2023

Primary Completion Date

May 23, 2025

Study Completion Date

December 31, 2026

Conditions
Unresectable or Metastatic Microsatellite Stable/Mismatch Repair Proficient Colorectal Cancer
Interventions
DRUG

LBL-007

Administered intravenously.

DRUG

Tislelizumab

Administered intravenously.

DRUG

Bevacizumab or Bevacizumab biosimilar

Administered intravenously

DRUG

Capecitabine

Administered in accordance with relevant local guidelines and/or prescribing information

DRUG

5-Fluorouracil

Administered in accordance with relevant local guidelines and/or prescribing information

Trial Locations (76)

2148

Blacktown Cancer and Haematology Centre, Blacktown

2298

Calvary Mater Newcastle, Waratah

2650

Riverina Cancer Care Centre, Wagga Wagga

2800

Orange Health Service (Central West Cancer Care Centre), Orange

3004

The Alfred Hospital, Melbourne

3084

Austin Health, Heidelberg

3168

Monash Health, Clayton

4101

Icon Cancer Centre South Brisbane, South Brisbane

4217

Pindara Private Hospital, Benowa

5042

Flinders Centre For Innovation in Cancer (Fcic), Bedford Park

5112

Lyell McEwin Hospital, Elizabeth Vale

6009

One Clinical Research, Nedlands

6150

St John of God, Murdoch, Murdoch

10016

Laura and Isaac Perlmutter Cancer Center At Nyu Langone Health, New York

10032

Columbia University Medical Center, New York

11501

Perlmutter Cancer Center At Winthrop Oncology Hematology Associatesnyu Winthrop Hospital, Mineola

22031

Virginia Cancer Specialists, Fairfax

27710

Duke Cancer Center, Durham

32207

Baptist Md Anderson Cancer Center, Jacksonville

37920

University of Tennessee Medical Center, Knoxville

40217

Norton Cancer Institute, Louisville

40503

Baptist Health Lexington, Lexington

40536

University of Kentucky Markey Cancer Center, Lexington

46804

Fort Wayne Medical Oncology and Hematology, Fort Wayne

59102

St Vincent Frontier Cancer Center, Billings

63110

Washington University School of Medicine, St Louis

70121

Ochsner Clinic Foundation, New Orleans

70433

Pontchartrain Cancer Center, Covington

75390

Ut Southwestern Medical Center, Dallas

78229

Ut Health San Antonio Mays Cancer Center, San Antonio

85234

Banner Md Anderson Cancer Center, Gilbert

87102

University of New Mexico Cancer Center, Albuquerque

89169

Comprehensive Cancer Centers of Nevada, Las Vegas

89511

Cancer Care Specialists, Reno

90033

Usc Norris Comprehensive Cancer Center (Nccc), Los Angeles

90067

Valkyrie Clinical Trials, Los Angeles

90095

UCLA, Los Angeles

90703

Toi Clinical Research, Cerritos

92663

Hoag Memorial Presbyterian, Newport

94510

Kaiser Permanente Northern California, Vallejo

98405

Multicare Health System Institute For Research and Innovation, Tacoma

99216

Cancer Care Northwest, Spokane Valley

99508

Alaska Oncology and Hematology, Llc, Anchorage

100034

Peking University First Hospital, Beijing

102218

Beijing Tsinghua Changgung Hospital, Beijing

130021

The First Hospital of Jilin University, Changchun

200000

Renji Hospital Shanghai Jiao Tong University School of Medicine, Shanghai

200072

Shanghai 10Th Peoples Hospital, Shanghai

200123

Shanghai East Hospital Branch Hospital, Shanghai

213000

The First Peoples Hospital of Changzhou, Changzhou

214122

Affiliated Hospital of Jiangnan University South Campus, Wuxi

215124

Nantong First Peoples Hospital, Nantong

230601

The Second Hospital of Anhui Medical University, Hefei

250117

Shandong Cancer Hospital, Jinan

266000

Qingdao Municipal Hospital, Qingdao

272000

Jining No.1 Peoples Hospital West Branch, Jining

276000

Linyi Peoples Hospital, Linyi

300060

Tianjin Medical University Cancer Institute and Hospital, Tianjin

300121

Tianjin Union Medical Center (Nankai University Affiliated Hospital), Tianjin

310009

The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou

350001

Fujian Medical University Union Hospital, Fuzhou

361003

The First Affiliated Hospital of Xiamen University, Xiamen

362000

Quanzhou First Affliated Hospital of Fujian Medical University, Quanzhou

410013

Hunan Cancer Hospital, Changsha

430079

Hubei Cancer Hospital, Wuhan

450000

Henan Cancer Hospital, Zhengzhou

473000

Nanyang Central Hospital, Nanyang

510000

Sun Yat Sen Memorial Hospital, Sun Yat Sen University (North), Guangzhou

Zhujiang Hospital of Southern Medical University, Guangzhou

515041

The First Affiliated Hospital of Shantou University Medical College, Shantou

730000

Gansu Provincial Hospital, Lanzhou

750004

General Hospital of Ningxia Medical University, Yinchuan

830001

The Xinjiang Uygur Autonomous Region Peoples Hospital, Ürümqi

834009

Karamay Central Hospital of Xinjiang, Karamay

030013

Shanxi Provincial Cancer Hospital, Taiyuan

00935

Pan American Oncology Trials, Llc, Rio Piedras

Sponsors

Lead Sponsor

All Listed Sponsors
lead

BeiGene

INDUSTRY

NCT05609370 - A Study Investigating the Efficacy and Safety of LBL-007 Plus Tislelizumab in Combination With Bevacizumab Plus Fluoropyrimidine Versus Bevacizumab Plus Fluoropyrimidine in Participants With Unresectable or Metastatic Colorectal Cancer | Biotech Hunter | Biotech Hunter