NCT05603104View on ClinicalTrials.gov

Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure

PHASE3RecruitingINTERVENTIONAL
Enrollment

1,254

Participants

Timeline

Start Date

April 27, 2025

Primary Completion Date

June 30, 2028

Study Completion Date

June 30, 2028

Conditions
Schizophrenia and Related DisordersMajor Depressive DisorderBipolar Depression
Interventions
DRUG

Clozapine

See arm description

DRUG

Esketamine Nasal Product

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DRUG

Escitalopram

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DRUG

Sertraline

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DRUG

Venlafaxine

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DRUG

Lithium

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DRUG

Valproate acid

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DRUG

Quetiapine

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DRUG

Second-line Antidepressants

See arm description

DRUG

Second-line Antipsychotics

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DRUG

Ketamine Hydrochloride

See arm description

DRUG

Esketamine hydrochloride

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DRUG

Bupropion

See arm description

Trial Locations (1)

Unknown

RECRUITING

Sheba Medical Center, Ramat Gan

All Listed Sponsors
collaborator

Universität Münster

OTHER

lead

Dr. Inge Winter

OTHER