ADP-A2M4CD8 Monotherapy and in Combination with Nivolumab in HLA-A2+ Subjects with MAGE-A4 Positive Ovarian Cancer (SURPASS-3)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

66

Participants

Timeline

Start Date

June 26, 2023

Primary Completion Date

August 12, 2026

Study Completion Date

August 12, 2026

Conditions
Ovarian Cancer
Interventions
GENETIC

Autologous genetically modified ADP-A2M4CD8 cells

Infusion of autologous genetically modified ADP-A2M4CD8 cells on Day 1

COMBINATION_PRODUCT

Autologous genetically modified ADP-A2M4CD8 cells in combination with Nivolumab

Infusion of autologous genetically modified ADP-A2M4CD8 on Day 1 followed by nivolumab 480 mg IV at Week 4 and then every four weeks

Trial Locations (23)

28027

Clinica Universidad de Navarra, Madrid

28034

Hospital Universitario Ramón y Cajal, Madrid

28040

Hospital Universitario Fundación Jiménez Díaz, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28050

Centro Oncologico Clara Campal, Madrid

30912

Augusta University, Augusta

44195

Cleveland Clinic Foundation, Cleveland

46010

Hospotal Clinico Universitario de Valencia, Valencia

48201

Karmanos Cancer Institute, Detroit

57105

Avera Cancer Institute, Sioux Falls

67200

Institut de Cancerologie de Strasbourg, Strasbourg

69008

Centre Leon-Berard, Lyon

69310

Institut de Cancerologie des Hospices Civils de Lyon, Pierre-Bénite

73104

University of Oklahoma Health Sciences Center, Oklahoma City

85258

Honor Health, Scottsdale

91010

City of Hope, Duarte

94805

Institut Gustave Roussy, Villejuif

98104

Swedish Cancer Institute, Seattle

08901

Rutgers Cancer Institute of NJ, New Brunswick

M5G 2M9

University Health Network (Princess Margaret Cancer Center), Toronto

08035

Vall d'Hebron Unversity Hospital, Barcelona

NW1 2PG

University College of London Hospital, London

M20 4GJ

The Christie Hospital, Manchester

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

GOG Foundation

NETWORK

lead

Adaptimmune

INDUSTRY

NCT05601752 - ADP-A2M4CD8 Monotherapy and in Combination with Nivolumab in HLA-A2+ Subjects with MAGE-A4 Positive Ovarian Cancer (SURPASS-3) | Biotech Hunter | Biotech Hunter