Nivolumab/Ipilimumab and Chemotherapy Combination in Advanced NSCLC Patients With HIV, HBV, HCV and Long Covid Syndrome

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

105

Participants

Timeline

Start Date

February 1, 2023

Primary Completion Date

December 31, 2026

Study Completion Date

March 30, 2027

Conditions
NSCLC Stage IVHIVHBVHCVLong COVID
Interventions
DRUG

Nivolumab and Ipilimumab

"Nivolumab will be administered with ipilimumab, plus 2 cycles of histology-based platinum doublet chemotherapy:~* Squamous histology: carboplatin AUC 6 + paclitaxel 200 mg/m2~* Non-squamous histology: carboplatin AUC 5 or 6 + pemetrexed 500 mg/m2 or cisplatin 75 mg/m2 + pemetrexed 500 mg/m Dosing: nivolumab 360 mg every 3 weeks + ipilimumab 1 mg/kg every 6 weeks (up to maximum 2 years) + histology-based, platinum doublet chemotherapy (every 3 weeks for two cycles)."

Trial Locations (1)

37134

Centro Ricerche Cliniche, Verona

All Listed Sponsors
lead

Universita di Verona

OTHER