964
Participants
Start Date
July 26, 2023
Primary Completion Date
August 6, 2024
Study Completion Date
March 13, 2025
Experimental: Paxlovid 25 day dosing
Drug: Paxlovid 25 day dosing Paxlovid (nirmatrelvir 300mg, ritonavir 100mg) bid x 25 days See NCT05965726 (Paxlovid Sub-study)
Experimental: Paxlovid 15 day dosing
Drug: Paxlovid 15 day Dosing Paxlovid (nirmatrelvir 300mg and ritonavir 100mg) bid x 15 days then ritonavir 100mg bid plus nirmatrelvir matching placebo bid x 10 days See NCT05965726 (Paxlovid Sub-study)
Placebo Comparator: Control
Drug: Control ritonavir 100mg taken bid plus nirmatrelvir matching placebo bid bid x 25 days See NCT05965726 (Paxlovid Sub-study)
Icahn School of Medicine at Mount Sinai, New York
Weil Cornell Medicine, New York
NYU Langone Health/Brooklyn Hospital, Brooklyn
St. Lawrence Health Medical Campus, Canton
UPMC Presbyterian Shadyside, Pittsburgh
Howard University Hospital, Washington D.C.
Jadestone Clinical Research, LLC, Silver Spring
Johns Hopkins Hospital, Baltimore
University of Virginia, Charlottesville
Sentara Norfolk General Hospital, Norfolk
West Virginia Clinical and Translational Science Institute, Morgantown
Wake Forest University, Winston-Salem
University of North Carolina, Chapel Hill
East Carolina University, Greenville
Duke Clinical and Translational Science Institute, Kannapolis
Emory Health Care, Decatur
Grady Memorial Hospital, Atlanta
Kaiser Permanente Southwood, Atlanta
Morehouse School of Medicine, Atlanta
University of Florida College of Medicine Jacksonville, Jacksonville
Valencia Medical and Research Center, Miami
Lakeland Regional Medical Center, Lakeland
University of Alabama at Birmingham, Birmingham
Clinical Trials Center of Middle Tennessee, Franklin
University of Mississippi Medical Center, Jackson
University of Kentucky Chandler Medical Center, Lexington
University Hospitals Cleveland Medical Center, Cleveland
MetroHealth System, Cleveland
Cleveland Clinic, Cleveland
Atlanta VA Medical Center, Atlanta
University of Cincinnati Medical Center, Cincinnati
Froedtert Hospital-Medical College of Wisconsin, Milwaukee
Mayo Clinic, Rochester
Avera McKennan Hospital & University Health Center, Sioux Falls
Lillestol Research, LLC, Fargo
North Shore University Health System, Evanston
Northwestern Memorial Hospital, Chicago
Rush University Medical Center, Chicago
University of Illinois at Chicago, Chicago
Koch Family Medicine, Morton
Methodist Medical Center of Illinois, Peoria
Saint Francis Medical Center, Peoria
Washington University School of Medicine, St Louis
University of Kansas Medical Center, Kansas City
Oklahoma Clinical and Translational Science Institute, Oklahoma City
Houston Methodist Hospital, Houston
University of Texas Health Science Center at Houston, Houston
University of Texas Health Science Center at San Antonio, San Antonio
University of Colorado, Aurora
University of Arizona/Banner University Medical Center Phoenix, Phoenix
University of Arizona Banner Medical Center, Tucson
University of New Mexico Health Science Center, Albuquerque
Cedars Sinai Medical Center, Los Angeles
Los Angeles Biomedical Institute at Harbor-UCLA Medical Center, Torrance
Hoag Memorial Hospital, Newport Beach
University of California San Francisco General Hospital, San Francisco
Stanford University, Stanford
Oregon Health and Science University, Portland
Swedish Health Services, Seattle
University of Washington, Seattle
Providence Medical Research Center, Spokane
Tufts Medical Center, Boston
Brigham and Womens Hospital, Boston
Boston Medical Center, Boston
Beth Israel Deaconess Medical Center, Boston
Dartmouth Hitchcock Medical Center, Lebanon
Rutgers University-Robert Wood Johnson Medical School, New Brunswick
Vermont Lung Center, University of Vermont, Colchester
Hispanic Alliance for Clinical and Translational Research, Univ of Puerto Rico, San Juan
Kanecia Obie Zimmerman
OTHER