SNF Platform Study of HR+/ HER2-advanced Breast Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

620

Participants

Timeline

Start Date

December 30, 2022

Primary Completion Date

December 1, 2025

Study Completion Date

December 1, 2026

Conditions
Breast NeoplasmBreast CancerHormone Receptor Positive TumorHER2-negative Breast CancerAdvanced Breast Cancer
Interventions
DRUG

PIK3CA inhibitor

PIK3CA inhibitor

DRUG

AKT inhibitor

AKT inhibitor

DRUG

Carrelizumab

Pd-1 mab

DRUG

Famitinib

VEGFR inhibitor

DRUG

Fluzoparib

PARP inhibitor

DRUG

Dalpiciclib

CDK4/6 inhibitor

DRUG

SHR-A1811

HER2 ADC

DRUG

Everolimus

mTOR inhibior

DRUG

Aromatase Inhibitors or Fulvestrant

Letrozole/Anastrozole/Exemestane or Fulvestrant

DRUG

Goserelin

For premenopause

DRUG

TPC

Treatment of Physicians' Choice (albumin-paclitaxel, capecitabine, vinorelbine, and irbribulin)

DRUG

Sorafenib

RTK Inhibitor

DRUG

Apatinib

Apatinib 250mg po qd

DRUG

SHR-A1921

TROP2 ADC

DRUG

SHR-A2102

NECTIN4 ADC

DRUG

SHR-A2009

HER3 ADC

DRUG

SHR-1167

PARP1i

DRUG

SHR-6209

CDK4i

DRUG

bevacizumab

bevacizumab

Trial Locations (1)

200032

RECRUITING

Breast cancer institute of Fudan University Cancer Hospital, Shanghai

All Listed Sponsors
collaborator

Peking University Cancer Hospital & Institute

OTHER

collaborator

First Hospital of China Medical University

OTHER

collaborator

Sun Yat-sen University

OTHER

collaborator

First Affiliated Hospital Xi'an Jiaotong University

OTHER

collaborator

Chongqing University Cancer Hospital

OTHER

collaborator

Northern Jiangsu People's Hospital

OTHER

collaborator

Fujian Medical University Union Hospital

OTHER

collaborator

Ningbo Medical Center Lihuili Hospital

OTHER_GOV

collaborator

Shanghai First Maternity and Infant Hospital

OTHER

collaborator

Shanghai 6th People's Hospital

OTHER

collaborator

Affiliated Hospital of Nantong University

OTHER

collaborator

Nanchang People's Hospital

UNKNOWN

collaborator

Liaoning Cancer Hospital & Institute

OTHER

collaborator

The Affiliated Hospital of Nantong University

UNKNOWN

collaborator

The First Hospital of Jilin University

OTHER

lead

Fudan University

OTHER