Study of Onvansertib in Combination With FOLFIRI and Bevacizumab Versus FOLFIRI and Bevacizumab for Second Line Treatment of Metastatic Colorectal Cancer in Participants With a Kirsten Rat Sarcoma Virus Gene (KRAS) or Neuroblastoma-RAS (NRAS) Mutation

PHASE2CompletedINTERVENTIONAL
Enrollment

23

Participants

Timeline

Start Date

March 17, 2023

Primary Completion Date

December 9, 2024

Study Completion Date

December 9, 2024

Conditions
Colorectal CancerMetastatic Colorectal Cancer
Interventions
DRUG

Onvansertib

Oral capsule

DRUG

FOLFIRI

FOLFIRI (irinotecan + fluorouracil \[5-FU\] + leucovorin) as intravenous (IV) infusion

DRUG

Bevacizumab

IV infusion

Trial Locations (27)

10016

Manhattan Hematology Oncology Associates, New York

22031

Inova Schar Cancer Institute, Fairfax

22903

University of Virginia School of Medicine, Charlottesville

32224

Mayo Clinic - Jacksonville, Jacksonville

33028

Memorial Hospital West, Pembroke Pines

38138

West Cancer Center - East Campus, Germantown

44106

University Hospitals Cleveland Medical Center, Cleveland

44718

Gabrail Cancer and Research Center, Canton

45236

Trihealth Kenwood, Cincinnati

49503

Cancer & Hematology Centers of Western Michigan - Lemmen-Holton Cancer Pavilion, Grand Rapids

55905

Mayo Clinic - Rochester, Rochester

63110

Washington University School of Medicine Center for Advanced Medicine, St Louis

68130

Nebraska Cancer Specialists - Midwest Cancer Center - Legacy, Omaha

77030

University of Texas MD Anderson Cancer Center, Houston

84106

Utah Cancer Specialists, Salt Lake City

85054

Mayo Clinic in Arizona - Phoenix Campus, Phoenix

87401

San Juan Oncology Associates, Farmington

90033

Norris Comprehensive Cancer Center, Los Angeles

90404

UCLA Health - Santa Monica Parkside Cancer Care, Santa Monica

90505

Torrance Memorial Physician Network - Cancer Care and Infusion Center, Torrance

90602

PIH Health, Whittier

90720

Cancer and Blood Specialty Clinic, Los Alamitos

92801

Pacific Cancer Medical Center, Anaheim

92868

UCI Health - Chao Family Comprehensive Cancer Center, Orange

93309

Comprehensive Blood and Cancer Center - Bakersfield, Bakersfield

72205-6523

Central Arkansas Radiation Therapy Institute - Cancer Center, Little Rock

07631

Englewood Health, Englewood

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Cardiff Oncology

INDUSTRY