A Study of Sulfatinib on Relapsed or Refractory Drug Resistant Osteosarcoma

PHASE1/PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

148

Participants

Timeline

Start Date

January 31, 2023

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2027

Conditions
Osteosarcoma
Interventions
DRUG

Sulfatinib

(1) Sulfatinib: 300 mg, oral once a day (QD), 21 days as a cycle

DRUG

Etoposide

(1) Etoposide: 100 mg/m2/day (initial dose) will be administered on the first to third days of each 21 day cycle, a total of 5 cycles. The dose of etoposide can be reduced to 80 mg/m2/day and 60 mg/m2/day.;

DRUG

Isophosphamide

(1) Isophosphamide: 3000 mg/m2/day (initial dose) will be administered on the first to third days of each 21 day cycle for 5 cycles. The dose of ifosfamide can be reduced to 2400 mg/m2/day and 1800 mg/m2/day.

Trial Locations (5)

100000

Peking University People's Hospital, Beijing

200000

Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai

200233

Department of Orthopaedic Surgery, Sixth People's Hospital, Shanghai Jiao Tong University,, Shanghai

250000

Qilu Hospital of Shandong University, Jinan

999007

Department of Orthopedic Surgery Chonnam National University, Donggu

All Listed Sponsors
collaborator

Chonnam National University

OTHER

collaborator

Peking University People's Hospital

OTHER

collaborator

Qilu Hospital of Shandong University

OTHER

collaborator

Ruijin Hospital

OTHER

collaborator

Shanghai Jiao Tong University Affiliated Sixth People's Hospital

OTHER

lead

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

NCT05590572 - A Study of Sulfatinib on Relapsed or Refractory Drug Resistant Osteosarcoma | Biotech Hunter | Biotech Hunter